Can a male calico cat have an extra X chromosome?

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Glenn Lucio asked a question: Can a male calico cat have an extra X chromosome?
Asked By: Glenn Lucio
Date created: Mon, Aug 15, 2022 8:13 AM
Date updated: Thu, May 16, 2024 4:54 AM

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Video answer: X Inactivation

X Inactivation

Best answer to the question Ā«Can a male calico cat have an extra X chromosome?Ā»

While itā€™s normal for female calico cats to carry two X chromosomes, male calicos carrying an extra X chromosome (XXY) is deemed as a genetic rarity. Fact is, out of 3000 female calicos, only one is born a male. Average Life Expectancy: How Long Do Calico Cats Live?

Frequently Asked Questions

Those who are looking for an answer to the question Ā«Can a male calico cat have an extra X chromosome?Ā» often ask the following questions:

šŸ˜» What percent of calico cats are male?

You may never actually encounter a male calico cat in your lifetime, but unlike the Loch Ness monster, they do exist! For every 3,000 cats with the coat pattern, roughly one is a boy -- approximately .03 percent. Genetics Calico cats, unlike say the Siamese, are not a breed but rather a genetic disorder of sorts.

šŸ˜» Are calico cats always female?

Calico cats are almost always females, with roughly 99.9% of all calico cats being female. Of course, in nature, there are always anomalies, and around one in every 3,000 calicos are male, but this is extremely rare. Male calicos are typically sterile and suffer from far more health issues than female calicos.

šŸ˜» What are male calico cats called?

They are called Klinefelter males and are less than 1 in every 1,000 calico cats. However, male calico cats often suffer from a condition called Klinefelterā€™s Syndrome since they bear an XXY chromosome. This is an abnormality that will impact the catā€™s lifespan.

Video answer: Calico cat's genetics

Calico cat's genetics

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We've handpicked 28 related questions for you, similar to Ā«Can a male calico cat have an extra X chromosome?Ā» so you can surely find the answer!

Do male calico cats have an extra X chromosome?
Unfortunately, the extra X chromosome can affect a male calico's health and vitality. According to a study published by the National Center for Biotechnology Information's (NCBI) Pub Med website, a condition called Klinefelter's Syndrome is associated with males that have an additional X chromosome.
Can a male cat have an extra X chromosome?
In rare cases, cats can have an extra X chromosome making them XXY. These cats present as male, but can be Calico because they have two X chromosomes. This XXY configuration can cause Klinefelterā€™s Syndrome, which is a health issue weā€™ll get into later.
Why do male calico cats have a shorter lifespan than females?
Male calicoes tend to live shorter lives than female calicoes because of a genetic condition called Klinefelterā€™s Syndrome. This syndrome is the presence of two X chromosomes and one Y chromosome ā€“ in other words, a male calico cat has an extra X chromosome.
Are male or female calico cats more likely to be healthy?
Females naturally have XX chromosomes, so it's not a surprise that the majority of calico cats are females. On the other hand, males cats naturally have XY chromosomes, so in order for a male to be calico, he has to have an extra X chromosome (XXY). Unfortunately, the extra X chromosome can affect a male calico's health and vitality.

Video answer: Why are Calico Cats Always Female?

Why are Calico Cats Always Female? What are the odds of a male calico cat being male?
There's less than a 0.1% chance of a calico cat being born male. Approximately one in 3,000 calicos are male. For a male cat to have calico colors, it must have an extra X chromosome, making it XXY. While these cats present as male, they are calico because of the double X chromosome. Meet Sherman, one in 3,000.
Are male calico kittens sterile?
In the rare instance of a male calico kitten being born, there is a 1 in 3,000 chance of it being sterile due to an abnormality in a male calicoā€™s genes, which causes him to have an extra X chromosome.
Is it possible for a male calico cat to be sterile?
Meanwhile, male calico cats usually have XY chromosomes. It is only possible for dilute male calico cats to exist if they get an extra X chromosome, making their configuration XXY. However, dilute calicos born with this additional chromosome can have Klinefelter syndrome and be sterile.
How rare are male calico?
While most calicos are female cats, not all of them are. Male calico cats are rare ā€” with an estimate of 1 in 3,000 calico cats being a male calico. They most likely have Klinefelterā€™s syndrome, a rare genetic condition found in male calicos thatā€™s from having an extra X chromosome in males.
Why are calico cats almost exclusively female?
As there are two X genes at play (O/o), calico cats are also almost exclusively female. As we know, for a cat to be tortoiseshell, it must have two X chromosomes, and male cats have an X and a Y. In rare cases, the male will have an extra X chromosome, making him XXY.
Can a male cat be a calico?
A cat needs two X chromosomes to be a Calico. Female cats have XX chromosomes, while most males have XY chromosomes, so of course, most Calicos are female. Some cats are born with an extra X chromosome, so their chromosomes are XXY. These cats are male, but because, like females, they have two X chromosomes, they can also be Calicos.

Video answer: Secrets of the X chromosome - Robin Ball

Secrets of the X chromosome - Robin Ball Why are calico and tortoiseshell cats different colors?
That extra X chromosome means a female can receive both a black and orange color gene, which gives rise to calico and tortoiseshell variations. ā€œFemales with a black gene on one X chromosome and an orange gene on the other X chromosome will be calico or tortoiseshell colored,ā€ says Bell.
Can a male cat be both a Klinefelter and a calico?
In fact, in order for a male cat to even carry and express both of these colors, he must have a genetic rarity known as Klinefelter syndrome. Klinefelter males have an extra X chromosome, so their genetic map is XXY. Because of the presence of the two X chromosomes, Klinefelter males can appear calico.
Why do calico cats have black and orange patches of fur?
The black and orange patches of fur that characterize these cats are a result of the genetic phenomenon called ā€œ X-chromosome inactivation ā€. In cats, the gene that dictates fur color is located on the X chromosome. Nearly all calico cats are female, so they have two X chromosomes. The rare male calico cats have one X and one Y chromosome.
How are calico cats rare and how do they exist?
While these cats present as male, they are calico because of the double X chromosome. Why are male calico cats so rare? Male calico cats are rare because like human males with Kleinfelterā€™s Syndrome, they suffer from a chromosomal abnormality in which they have 2 X chromosomes along with the Y, instead of one. Color in cats is carried on the X chromosome.
How many X chromosomes does a calico cat have?
In cats, the gene that dictates fur color is located on the X chromosome. Nearly all calico cats are female, so they have two X chromosomes. The rare male calico cats have one X and one Y chromosome.
What is the genetic map of a Klinefelter male?
Klinefelter males have an extra X chromosome, so their genetic map is XXY. Because of the presence of the two X chromosomes, Klinefelter males can appear calico. Klinefelter syndrome is named after the doctor who first described it in humans.
Can a male cat be a tortoiseshell?
As male cats have only one X and one Y chromosome, that means that it is technically almost impossible from a genetic standpoint for a male to inherit the gene for tortoiseshell coloring. The rare male tortoiseshell would have an extra X chromosome, making it an XXY, a symptom of Klinefelter Syndrome.
Can a male cat have a tortoiseshell color?
Male cats only have one X and one Y chromosome, so technically itā€™s genetically almost impossible for a male to inherit the tortoiseshell coloring. A male tortoiseshell has an extra X chromosome, making it an XXY. According to a study by the College of Veterinary Medicine at the University of Missouri, only 1 in 3000 tortoiseshell cats is male.
Can a male calico cat be black and orange?
Since males have only one X chromosome, they only have one black or orange gene and can only display orange or black (plus or minus white, controlled by another gene). Male Calico Cats. Calico cats are not always female. Male calico cats do exist and typically have a chromosomal aberration of two X chromosomes and one Y chromosome (XXY).
What makes a calico cat?
It takes a very unusual chromosome pattern to create a calico cat. The X chromosome carries the genes for color. Females have two X chromosomes while males have just one. For a cat to become calico, it must have an X chromosome with orange coloring and another X chromosome with black coloring.
Can a male calico cat have two X chromosomes?
The rare male calico cats have one X and one Y chromosome. In addition to determining a catā€™s coat color, X chromosomes have numerous genes that code for proteins that are necessary for survival. With females having two X chromosomes, this double dose of ā€˜survivalā€™ genes could be toxic.
Why can't male cats be Calico?
Because male cats have one X chromosome with code for black or orange and one Y chromosome with no color genes, they cannot technically be calico. They'll only express either black or orange, but not both.
What percent of calico cats are female?
What percentage of calico cats are female? 99.9667% of calico cats are female, or 2,999 our of 3,000. The remaining 0.003 percent consists of physically male cats with an extra X chromosome, making them XXY. Only one in 3,000 calicos is male and only one in 10,000 of these males is fertile.
Can a male cat be Calico?
In most cases, males are only one color (for instance, black) as they have only one X chromosome. Hence, they cannot be calico, unless they are affected by a rare genetic condition called Klinefelter syndrome, which gives them two X chromosomes and one Y chromosome.
Do male calico cats exist?
Though it is very rare, male calico cats do exist. Male calico cats are most likely to have a chromosomal abnormality that gives them two X chromosomes and one Y chromosome (XXY). How long do calico cats live?
Why are male calicio cats so rare?
Male calico cats are so rare simply because of the genetics required for calico fur. Orange and black fur is coded in the X chromosome. To have both, you need two X chromosomes. In healthy creatures, females receive two X chromosomes, while males only receive one.
What makes a cat a calico?
ā€œFor a cat to be a calico, it must have two X chromosomes, and typically only female cats have two X chromosomes, says Dr. Stephanie Karpf, a veterinarian at For Cats Only in West Palm Beach, Florida. That extra X chromosome means a female can receive both a black and orange color gene, which gives rise to calico and tortoiseshell variations.
Are most calico cats female?
Yes, for the most part. Because their coloring is linked to the X chromosome and cats with two X chromosomes (XX) are female, 99.9% of all calico cats are female. It is possible for a calico cat to be male, but it is exceedingly rare. Can calico cats be male?

Video answer: X inactivation mechanism

X inactivation mechanism